I like the Organic Acids Test from Great Plains to evaluate for methylmalonic acid. For overall B12 a serum does okay, along with checking blood indices, i.e. Hemoglobin, hematocrit, mean corpuscular volume (MCV), along with B12. However, one thing to keep in mind is methyl-b12 for special needs kids is not determined based on blood levels or MMA levels. The need is often based on biochemical need for that form of B12 to augment the methylation cycle versus trying to overcome a deficiency of B12.
Sincerely,
Dr. Woeller