TMG vs DMG and elevated Taurine

[Aaron Hartman]

I have a patient who is on high dose B12 and 5MTHF and still having methyltion issues. Mainly due to CBS + status resulting is high levels of Taurine and Ammmonia. Would in this case TMG be the preferred suppliment to help offset this?

[DrWoeller]

Dr. Hartman,
Is this the same person from the other post?

If so, curious as to their SNPs:

-NOS
-COMT
-MTHFR
-BHMT

Dr. Woeller

[Aaron Hartman]

Yes, same person.
I make my posts as questions come up which I go through the webinar info.
SNPs are

MTHFR C677T +/- MTR A2756G +/- MTRR A66G +/+ MTRR 11 +/+ NOS -/-

BHMT 2 +/- BHMT 4 +/- BHMT 8 +/- CBS C699T +/- COMT V158M +/+ COMT H62H +/+

VDR Taq1 +/+ VDR Fok1 +/- MOA A +/- ACAT +/-

[DrWoeller]

Dr. Hartman,
Because of the elevated ammonia and taurine, which definitely could be coming the gut dysbiosis, I would also add some activated charcoal (AC) – one to two capsules daily (what for constipation. Can add some magnesium oxide if needed), and alpha-ketoglutate (AKG) – 300mg daily. The AC will help to bind up gut toxins, and the AKG will help to process ammonia.
Dr. Woeller

[Aaron Hartman]

Thanks
She is already taking one AC capsule daily.
What is the purpose of the AKG? How does it help process NH4?
Thanks
Aaron

[DrWoeller]

One of its effects is to complex amino groups and deliver through the urea cycle.
Dr. Woeller

P.S. it is a double-edge sword though in that it is also involved in the glutamate production which should then be converted to GABA.

[Author]

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