Dr. Parker,
Yes, most handle the methylated B’s, including those in Spectrum-Mate. There are always a few that get hyper and agitated, but not many. Overall, the methyl-folate is relatively small. I am all about working the percentages, particularly in the beginning. Many of these kids are deficient in nutrients and biochemically compromised. It’s been my experience these starter supplements help to fill in the gaps nutritionally to get things rolling. About 90% or more do just fine with the starter supplements.
There are actually some who are deficient, but best tested for in the blood. Not always easy to do, but if you are going to get blood then try adding the Copper and Zinc Profile from Great Plains Laboratory. Overall, I typically avoid Copper, but that also means I am not pushing for high levels of Zinc. I will use Zinc, in addition to the Spectrum-Mate, but unless I have confirmation of low Zinc in the beginning I will hold on it for later.
If you are working on genetic variations than by all means tailor your approach as needed.
I hope this helps.
Sincerely,
Dr. Woeller