Copper/Zinc ratios
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Hi Dr. Woeller,
Can you please advise how to determine a ratio from two serum tests? For example, my client has a serum copper level of 1.11 mcg/ml in a range of .75 – 1.45
and a serum zinc level of .78 mcg/ml in a range of .66 – 1.10.Much appreciated,
LynnLynn,
Are you talking about something like this from Great Plains Copper and Zinc Profile – http://static1.squarespace.com/static/560ac814e4b067a33438ecea/t/563cf15de4b00c9a5ef6b6a2/1446834525588/Copper+Zinc+ProfileSampleReport.pdf – Where the ratio is 0.8 to 2.0 for Copper/Zinc?If so, then your patients value would be 1.42 which is normal.
Sincerely,
Dr. WoellerDr. Woeller,
Currently, the markers were indicated by Mayo Clinic. I was wondering if there was a means to calculate the ratio.Respectfully,
LynnLynn,
I am not exactly sure what you are asking. I believe the ratio and individual calculation of zinc and copper, and the potential problems, comes from the work of William Walsh and the Pfeiffer Treatment Institute – at least some of it does. I don’t personally know as far as other medical literature. Certainly in Wilson’s Disease the copper is a problem.Dr. Woeller
According to Walsh, serum copper : plasma zinc ratio should ideally be 0.8 to 1.0
According to him, bipolar is commonly associated with ratio of 1.2 and higher. I don’t think Walsh has published anything in peer-reviewed journals, which many practitioners hold issue with.
Your patient’s ratio of 1.4 is high. But looks like you got serum zinc rather than plasma; not sure if that gives a different value than plasma, probably not.
Here’s a walsh calculator online: https://instacalc.com/39852
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