Extremely sensitive to supplements,
- This topic has 12 replies, 2 voices, and was last updated 7 years, 7 months ago by
.
-
Posts
-
Hello Dr. Woeller,
I’ve come to a stand still with a client that I’ve been working with for nearly one year. He is 17y.o., has higher functioning autism and experiences seizures. He is EXTREMELY sensitive to any new addition (in supplements as well. If the parents attempt to support him with a supplement, such as Vitamin C, glutathione (topical),Vitamin E, B6,B12 as methylcobalamin, B12 (as hydroxycobalamin (COMT+) Magnesium Citrate, molybdenum, a probiotic (All supplements need as identified in his OAT), the client shows an increase in seizures. Please note the parent separates the capsules and “sprinkles” as an introduction. I’ve been suspicious of detoxification issues and we began slowly adding in epsom salts to increase the sulfation phase. The parents report a “skunk” like body odor. My suspician is that he’s very toxic.
The client is taking a MV and fish oil and Sonic Cholesterol (his levels remain at 120) and is an extremely picky eater.
His OAT presents with yeast, oxalates, low glutathione, high HVA/low VMA(possibly the dopa hydroxylase issue). Regardless, he can not tolerate any new introduction of a supplement thus far.
Additional tests he’s had is an AA serum profile (elevated glycine and beta-alanine, low ethanolamine). And 23andme genetic testing (homozygous for GSTP1, NAT2,BHMT08 and heterozygous for COMT). He does show low Immunoglobulin A,G and M.
I’ve explored liver detoxification panels that assess Phase 1 and 2 but can’t seem to find one in the states, or that ships to us.
I would appreciate your input, thoughts, feedback and as always, your expertise.
Lynn
Lynn,
Where does this family live?You are correct in that this individual is likely very toxic. The sensitivity to supplements is just not normal and in every circumstance I have seen is from internal toxicity (which could come from environmental sources too).
I would suggest running and GPL-TOX and Glyphosate test from Great Plains and when their new MycoToxin panel comes out in August (hopefully), run that too. A missing component to the toxicity issue has been mold toxins and I believe this will be important information to have.
Also, do a Hair Analysis too.
Dr. Woeller
Thank you Dr.Woeller. The child shares his time with his mother in Sarasota Florida and the father in upstate New York- both humid places.
I will recommend these lab tests to the family. This child cannot tolerate even a sprinkle from the Klaire ther-biotic. The information from these results may be critical but supporting him again may be the challenge.
What are your thoughts on elevated Glycine and beta-alanine? Also, do you know of a detoxification panel?
Respectfully, Lynn
I should also mention that this child, like most of my other clients, is taking an AED, a benzodiazepine and CBD(per the family).
Lynn,
The elevated Glycine could contribute to high oxalates. Beta-alanine is typically linked to protein digestion I believe.I believe Meta-Metrix or Genova has a Phase I and Phase II detoxification panel. Check their website to see for sure. His GSTP1 points to a polymorphism in glutathione production so I wouldn’t be surprised if his Phase I and II were off.
There is a lot of spraying in Florida, both in Glyphosate and Organophosphate. The MycoToxin test will be important and then we will all figure out together how to treat these toxins when they are present. It’s a new science right now, but important.
Dr. Woeller
Hello Doctor Woeller,
The results are in for GPL-Tox (low results .38 in a reference range of 1.8 to 2.5). His Hair analysis results are attached. The only supplements he can tolerate (without an increase in activity) is the Spectrum Mate, Digestive Enzymes and Total Cholesterol (repeatedly comes in at 120).
His hair analysis shows elevated arsenic and barium; high normal level for zinc (interesting); low molybdenum (couldn’t tolerate even 25mg); low lithium, copper and iron.
I’ve had no success with locating a detoxification panel in the U.S. Genova has stopped offering that panel.
I would greatly appreciate your thoughts on how to move forward with this challenging (for me ) case.
Respectfully,
LynnLynn,
The low level of Lithium is concerning. This will make his brain and nervous system more sensitive to excitotoxins and excitatory reactions. Lithium is an NMDA receptor regulator and without it there is increased potential for high brain/nervous reactions, e.g. hyperexcitable, anxious.Where you able to get a GPL-TOX Panel. I see that the glyphosate is low which is good.
The fact that his metal levels are so low makes me suspicious of stored metals. This is where things get challenging is treatment intervention starts to get used contrary to what a lab indicates.
This is the type of person I would try and do some sauna intervention with, as well as Ion Foot Cleanse therapy to support detoxification.
Does he sweat?
Dr. Woeller
Thank you Dr. Woeller,
To address you questions:
1. Yes, he sweats with a skunk-like odor, especially when exposed to low dose epsom salt baths. He does get physical activity daily (indoors). He lives in Florida which also promotes sweating during the summer months.
2. The parents had tried single lamp infrared therapy but saw an increase in seizure activity.
3. Thank you for the reinforcement of the low levels of lithium. I will make this recommendation.
4. I will also reinforce the Ion Foot cleanse.
Additionally, I’ve been reading on the Cytochrome P450 Enzyme and how AED’s increase the activity of this enzyme, subsequently reducing the enzyme’s ability to breakdown Vitamin D, for example. This same enzyme (as you’ve discussed in your teachings as well) is responsible for manufacturing cholesterol. This client’s cholesterol remains at 120 total regardless of supplementing with Sonic Cholesterol (2 per day). Again this leads me back to toxicity. Am I understanding this correctly?Regards,
LynnLynn,
I know a lot of acronyms, but AED? What is this again?Skunk-like odor can be linked to ammonium production which would hint at poor detoxification capacity, which would make sense from his extreme sensitivity to supplements.
I know you mentioned glutathione, B12, etc. all seems to increase seizure activity.
Somehow, this individual needs to be detoxed and the only ways I know at this point that don’t involve oral supplements is infra-red sauna and Ion Foot Cleanse. I would start with the foot cleanse approach first for a few months, then look to incorporate sauna therapy. This is a difficult situation because of his sensitivity so the process is going to take time.
I believe as he becomes more accustomed to foot cleanse he will become more tolerant of supplements, then sauna could be done.
Contact Terri Hirning at Real Food Mum – http://www.RealFoodMum.com. She can provide you will more information on the Ion Foot Cleanse or you can have the parents contact her. Let her I know I referred you. She has a son recovered from autism and the foot cleanse was a significant intervention in his recovery.
Sincerely,
Dr. WoellerThank you Dr. Woeller. I’ve been out of cell service for a few days so my apologies for the delayed reply.
AED is for antiepileptic drug.
Interesting about the ammonia levels and the “skunk-like” odor. My client did have elevated orotic on the OAT. Alpha-ketoglutaric acid was recommended but his body rejected this supplement.
I appreciate these resources and will let you know how the ion foot cleansing. Hopefully that will be our gateway to promoting healing.
Respectfully,
LynnLynn,
I hope the Ion Cleanse helps. At this point, I think its a good option because of this individuals extreme sensitivity to most things oral.Dr. Woeller
- You must be logged in to reply to this topic.